Medicinal mushrooms have been around since recorded history. These cool little fungi have been used in traditional medicine for thousands of years in ancient cultures such as Traditional Chinese Medicine (TCM), Ayurveda and Native American healing practices. From boosting immune system to reducing stress and inflammation, medicinal mushrooms are nature’s wisdom for health and wellness.

In today’s world, scientific research has validated many of the traditional uses, revealing the vast and varied therapeutic benefits of mushrooms. Active compounds like beta-glucans, triterpenes, antioxidants and polysaccharides are responsible for their amazing health benefits.

Whether powdered and taken as mushroom supplements, brewed into teas or added to food, these mushrooms can fortify your body from the cellular level out. With holistic health on the rise, now is the time to explore some of the most scientifically backed medicinal mushrooms and how you can harness their wellness benefits from your own home.

In this guide, we’ll explore 5 of the best medicinal mushrooms for health and wellness and how each can benefit your vitality, longevity and overall wellbeing.

1. Reishi (Ganoderma lucidum)

Health Focus: Immune Support & Stress Relief

Known as the “mushroom of immortality," Reishi is one of the most famous medicinal mushrooms in history. Old Chinese and Japanese texts have praised Ganoderma lucidum for its many health benefits, including prolonging life, enhancing Qi (life energy) and spiritual enlightenment.

Reishi is primarily used for its adaptogenic properties in modern wellness practice, meaning it helps the body adapt to stress and maintain homeostasis.

Reishi Benefits

Immune Modulation

Reishi contains beta-glucans, polysaccharides and triterpenes that modulate immune responses. This means it helps regulate overactive immune responses—useful for conditions like allergies or autoimmune diseases—and underactive immune responses, boosting the body’s ability to fight off infections. These immune-modulating properties are particularly beneficial in cancer treatments, as they can strengthen the immune system of patients undergoing therapy and help reduce side effects.

Stress and Sleep Support

As an adaptogen, Reishi balances the hypothalamic-pituitary-adrenal (HPA) axis, which controls the body’s stress response. Its triterpenoid content is also known to promote relaxation and support sleep, making it a natural remedy for sleep disorders and stress-induced anxiety.

Cardiovascular Health

Reishi has been shown in studies to support cardiovascular health by improving blood circulation, lowering blood pressure and reducing cholesterol.

How to Grow Reishi at Home

Reishi can be grown at home with pre-made grow kits, which simplifies the process. These grow kits come with Reishi spores and step-by-step instructions.

With patience, good water and right temperatures, you can have a sustainable source of immunity-boosting Reishi mushrooms right in your own home. They can be dried into extracts, teas and tinctures—making it easy to add to your daily wellness routine.

2. Lion’s Mane (Hericium erinaceus)

Health Focus: Brain Health & Cognitive Support

Lion’s Mane is a unique mushroom—both in appearance and benefits—that’s gained a lot of attention especially in brain health.

Its name comes from its shaggy, cascading spines that look like a lion’s mane and it’s commonly found growing on hardwood trees in North America, Europe and Asia. Traditionally, it was used in Chinese medicine to enhance cognitive function. The best part is that modern research has just uncovered the mechanism behind its mental health benefits.

Lion’s Mane Benefits

Neuroprotection and Cognitive Enhancement

The bioactive compounds in Lion’s Mane, hericenones and erinacines, have been found to stimulate the production of nerve growth factor (NGF).

NGF is a protein that’s essential for the growth, maintenance and survival of neurons. Studies show that Lion’s Mane may support neural plasticity—your brain’s way of adapting and forming new neural connections—which enhances cognitive function and improves memory and learning.

Mental Clarity and Focus

Research suggests that Lion’s Mane can alleviate brain fog by enhancing blood flow to brain tissue. Increased neuronal activity has been linked to clearer mental clarity without the jitters of caffeine. Some also report improvement in creativity and problem solving.

Potential Benefits for Neurodegenerative Conditions

Emerging research suggests that Lion’s Mane may delay or prevent neurodegenerative diseases like Alzheimer’s or Parkinson’s by promoting brain resilience and regeneration.

How to Grow Lion’s Mane at Home

Lion’s Mane can be grown indoors with grow kits that provide the right environment for fruiting. These spiny, pom-pom-like mushrooms need a wood-based growing medium (like hardwood sawdust) and high humidity. The fun part of growing Lion’s Mane at home is that you can watch them grow and have a steady supply of fresh, cognitive-enhancing mushrooms to add to stir-fries, brew into teas, or blend into smoothies.

3. Shiitake (Lentinula edodes)

Health Focus: Immune Support, Heart Health & Overall Wellness

Shiitake is one of the most well-known mushrooms globally, featured in many Asian dishes. While it’s loved for its savory, umami flavor, this popular mushroom has a medicinal history, especially in Japanese and Chinese medicine, where it’s used to fortify health and wellness.

Shiitake Benefits

Immune Support

Shiitake mushrooms have beta-glucans that stimulate the activity of immune T-cells and macrophages—the cells that fight off pathogens.

Lentinan, the polysaccharide in shiitake, has been researched for its immunomodulatory effects and may even enhance anti-tumor activity, contributing to cancer prevention.

Heart Health

Shiitake benefits also extend to heart health due to the presence of eritadenine, a compound that lowers blood cholesterol. Its polysaccharides also helps in blood pressure regulation.

Antimicrobial and Anti-Inflammatory Benefits

Shiitake has antimicrobial and antiviral properties and helps the body fight infections and reduce inflammation.

How to Grow Shiitake at Home

Growing Shiitake at home is fun for mushroom enthusiasts as it requires a wood-based substrate like oak logs or sawdust blocks.

Also, Shiitake mushrooms are easy to grow indoors or outdoors, so it’s one of the more accessible medicinal mushrooms for beginners to grow. Their rich flavor is versatile and can be used in many dishes, from soups to sautés. It’s easy to add these immune-boosting mushrooms to your diet.

4. Chaga (Inonotus obliquus)

Health Focus: Antioxidant Boost & Immune Function

Few mushrooms are as striking and powerful as Chaga. The charcoal black exterior of Chaga doesn’t look like other soft-bristled mushrooms; it looks like burnt bark.

Found on birch trees in cold climates (Siberia, Canada, Northern Europe), Chaga is called a super antioxidant-rich fungus. It has been used for centuries as a tonic to boost immunity, vitality and beauty.

Chaga Benefits

Extreme Antioxidant Richness

Chaga mushrooms are a treasure trove of antioxidants—polyphenols and superoxide dismutase (SOD)—which play vital roles in combating oxidative damage and preventing cellular aging. Antioxidants neutralize free radicals, which are linked to many chronic diseases like cancer, diabetes and cardiovascular diseases. They are also rich in vitamin D, which is essential for bone health and immune function.

Immune Function

Chaga mushrooms have impressive immunomodulatory effects, boosting the body’s natural defense by increasing the production and activity of immune cells. It's also used as an antiviral and anti-inflammatory agent.

Digestive Health

Chaga has been used to treat digestive issues, especially ulcers and digestive infections.

How to Harvest or Use Chaga

While growing Chaga at home is challenging since it’s symbiotic with birch trees, it’s more sustainable to harvest it wild with proper training or certifications (from trained foragers).

Once harvested, Chaga can be dried and made into fine powders, tinctures or brewed into nutrient dense teas, so this superfood is available to anyone who wants to get its benefits.

5. Cordyceps (Cordyceps militaris)

Health Focus: Energy, Stamina and Immune System Enhancement

Cordyceps has the most interesting origin story of any mushroom—it was first discovered by Himalayan herders who noticed their livestock became unusually strong after grazing on the Cordyceps fungus. Often considered a favorite in the herbal arsenal of athletes and fitness enthusiasts, Cordyceps mushrooms has natural compounds that boost physical performance, endurance and overall vitality.

Pro Tip: Cordyceps militaris is the most common cultivated species.

Cordyceps Benefits

Energy and Vitality

Cordyceps increase adenosine triphosphate (ATP) production, which is the primary energy-carrying molecule in cells. This increases cellular energy and overall stamina so it’s a favorite among those who wants to improve exercise performance and reduce fatigue.

Oxygen Uptake and Athletic Performance

Cordyceps has cordycepin and adenosine which increases oxygen intake in the body, improves lung capacity and circulation, making it great for athletic endurance and performance.

Immune System Enhancement

Cordyceps doesn’t just provide physical endurance; it’s also an immunomodulator that boosts the body’s natural defense by activating white blood cells like macrophages and natural killer (NK) cells to fight infections. Additionally, the bioactive compounds in Cordyceps can influence cell growth, supporting cellular health and potentially aiding in cancer therapy.

How to Grow Cordyceps at Home

Cordyceps militaris is one of the varieties that can be grown at home with grow kits designed for simplicity and ease. These mushrooms grows on nutrient rich substrates and can thrive in controlled and humid environment.

Add homegrown Cordyceps to your fitness smoothie or post workout meal and get natural energy without synthetic supplements.

Gut Health and Mushrooms

The gut can’t be ignored when it comes to overall wellness. Proper gut function is important for digestion, immune resilience, mood regulation and cognitive health.

Interesting research shows that certain medicinal mushrooms act as prebiotics for gut health. These prebiotic fibers stimulate the growth of good gut bacteria like Lactobacillus and Bifidobacterium, which are important to a healthy intestinal wall, reduced inflammation and overall digestive health.

Among mushrooms, Lion’s Mane, Reishi, and oyster mushrooms are the most notable for gut health.

Reishi has immune balancing prebiotics that help balance healthy gut flora. It also has anti-inflammatory properties that soothe intestinal irritations.

Lion’s Mane does double duty by also promoting neurological health through gut-brain axis communication, which is now linked to anxiety, depression and irritable bowel syndrome (IBS).

Oyster mushrooms are low in calories and carbohydrates while being high in essential vitamins and minerals. They possess antioxidants that may help reduce the risk of diseases such as cancer, heart disease, and diabetes, contributing to overall gut health.

By including these mushrooms in your diet—through meals, teas or supplements—you can build a stronger gut microbiome, alleviate digestive issues and boost immunity and brain function.

Why Mushroom Compounds Are Unique in Immune Health

What makes medicinal mushrooms different from other superfoods or supplements in boosting the immune system is the specificity of their compounds. The high concentration of beta-glucans in Reishi, Shiitake and Cordyceps is particularly unique.

Beta-glucans are polysaccharides that stimulate immune system activity by naturally triggering the body’s first line of defense: macrophages and natural killer (NK) cells. These large sugar molecules binds to receptors on immune cells and increase activity in fighting off viruses, bacteria and abnormal cells (like cancer cells).

Consuming mushrooms with beta-glucans regularly can:

• Increase resistance to infections like flu or viruses.

• Reduce inflammation which is the underlying cause of many chronic diseases.

• Support recovery from illness or physical stress.

Each medicinal mushroom has additional benefits specific to different needs and conditions so they are a versatile tool in building and maintaining immune resilience.

How to Incorporate Mushrooms in Daily Life for Maximum Health

The benefits of medicinal mushrooms is best felt when they are part of your daily wellness routine.

Luckily, mushrooms are versatile—whether fresh, dried or powdered forms. Whether you sip Reishi tea in the evening, mix Cordyceps powder in your morning smoothie, or sauté Shiitake mushrooms in your dinner, these powerful fungi makes it easy to support high quality health without complicated routines.

Turkey tail is another excellent option, known for its potential health benefits such as boosting immune response and its use in cancer treatment.

Tip: Incorporate turkey tail into your daily routine by adding it to teas, smoothies, or taking it as a supplement.

Here’s some ideas to get you started:

1. Lion’s Mane is great for daytime productivity. Try it as part of your nootropic morning booster in coffee or as a supplement for focus during work.

2. Reishi tea at night is great for unwinding and sleeping.

3. Add fresh Shiitake mushrooms to your stir-fries, soups and salads. Eating them in their natural form amplifies the anti-inflammatory and immune boosting effects.

For maximum control of your wellness journey and to have fresh and chemical free mushrooms – growing your own mushrooms can be a very rewarding and sustainable practice.

Supporting Your Wellness Journey with Mycology Kits and Supplies

You can take your health conscious lifestyle to the next level by growing your own mushrooms. With the right equipment and kits, growing mushrooms at home is easy, even for beginners. Imagine having nutrient-dense, medicinal mushrooms like Reishi, Shiitake, Lion’s Mane and Cordyceps fresh from your kitchen whenever you need them.

Growing Your Own Mushrooms Has Many Benefits

Sustainability

Homegrown mushrooms reduces your reliance on commercially processed supplements or extracts. Less nutrients are lost during harvesting so you get the most potent health benefits.

Convenience

You’ll have fresh mushrooms whenever you need it without worrying about quality control.

Rewarding Experience

Growing your own natural superfoods is a fulfilling personal experience that contributes to not just your health but mental well-being. Start your home cultivation now with easy to use grow kits and take control of your wellness journey!

How Mushrooms Fit into Holistic Health

It’s important to see medicinal mushrooms as part of a bigger holistic approach to health. Mushrooms provides a treasure trove of therapeutic benefits but optimal wellness is achieved through a synergy of many practices, including:

Balanced Nutrition: Pair the nutrient dense benefits of mushrooms with a diet rich in vegetables, fruits, proteins, and healthy fats.

Exercise: Mushrooms like Cordyceps that boost energy and oxygen uptake work well with an active lifestyle.

Mindfulness and Stress Reduction: Since mushrooms like Reishi helps with stress management, pair it with practices like meditation, yoga or deep breathing to support mental clarity and balance.

Sleep Hygiene: Sleep is essential for health and mushrooms like Reishi and Lion’s Mane can help you sleep better for recovery and overall vitality.

Taking an integrative approach means long term sustainable health where medicinal mushrooms are powerful tools to nourish and renew your mind, body and spirit.

Take Control of Your Health Journey Through Mushrooms

Nature has plenty to offer and in the form of medicinal mushrooms, it has a potent and centuries old solution for health and wellness. The mushrooms we’ve covered—Reishi, Lion’s Mane, Shiitake, Chaga and Cordyceps—have different benefits, from brain regeneration to immune support, energy boosts and stress relief.

Getting medicinal mushrooms into your life, whether through diet or home cultivation, means you take control of your health naturally and holistically. Start your journey now by entering the world of medicinal mushrooms and integrating their benefits into your lifestyle. Whether you’re brewing Chaga tea, adding Lion’s Mane to your brain supplement, or enjoying a savory Shiitake dish, medicinal mushrooms has something for everyone who cares for their wellness.

Why wait? Grow your own mushrooms with our kits, reap the benefits and level up your wellness journey

Key Points:

• Immune Support: Mushrooms like Reishi, Shiitake, and Cordyceps contain beta-glucans and other compounds that modulate immune responses, making them great allies against infection and inflammation.

• Cognitive Health: Lion’s Mane is excellent for neuronal regeneration, focus, memory, and overall brain health.

• Antioxidant Power: Chaga is rich in antioxidants, especially polyphenols and SOD compounds, which fight oxidative stress and cellular aging.

• Energy and Endurance: Cordyceps is popular in the fitness community for increasing ATP production, leading to more stamina, oxygen efficiency, and recovery.

• Stress Relief: Reishi is the premier adaptogen that supports stress management, reduces anxiety, and promotes sleep, making it great for times of stress.

• Easy to Integrate into Daily Life: Mushrooms can be easily added to meals, teas, powders, or supplements, making it easy to enjoy the benefits daily.

• Grow at Home: Home mushroom cultivation with grow kits is an eco-friendly and fulfilling way to have better access to fresh and healthy fungi.

Empower yourself with nature's original superfoods—start growing your wellness today!