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- A 2021 patent suggests cannabis and psilocybin may boost therapy effects by working together on serotonin receptors.
- Weed can make LSD and mushroom trips stronger and less predictable. This could cause worry or too much sensory input.
- Using weed when coming down from psychedelics might make the effects last longer or bring back trip feelings. This can make it harder to get back to normal.
- Mixing weed with MDMA can make you feel more happy but can also put stress on your heart if you're not careful.
- Using psychedelics and weed together might make HPPD more likely, especially for people with mental health issues.
Mixing weed and psychedelics is becoming more common for people using drugs for fun or to think in new ways. Cannabis and classic psychedelics like psilocybin, LSD, and even MDMA have strong effects on the brain and change feelings and what you see. Mixing them can make things more intense, like deeper thoughts, great visuals, and easier trips. But it's not always clear what will happen. This guide looks at how weed works with psychedelics, if it's helpful or not. And it gives simple, safe advice for anyone thinking about mixing them.
Key Things to Know Before Mixing
Before trying to mix weed and psychedelics, it helps to know how each one might affect your body and mind. Things like how much you take, how used to it you are, how you feel, and where you are all matter. The strong way weed and psychedelics work together can make a trip better or worse, mostly if you are new to this or have mental health problems.
Understand Your "Set and Setting"
"Set and setting" are key when using psychedelics. Your "set" is your mindset, how you are feeling and thinking before you start. "Setting" is where you are and who you are with. Mixing weed with psychedelics can make good and bad things stronger in both of these areas. If you feel nervous or lost, weed might not calm you down. It could make you feel worse.
Establish Your Intention
Are you mixing weed and psychedelics because you are curious, want to heal, for fun, or to connect with people? Knowing why you are doing it can change what happens. Even if you use weed a lot, mixing it with a psychedelic trip can make your body and mind react in ways you don't expect.
Mixing Basics for Safety
- Never use psychedelics and weed at the same time unless you really know what you are doing.
- Wait until you feel the psychedelic effects before adding weed.
- Think about your past mental health. Mixing things can make mental health problems worse.
- Have a trip-sitter. This is someone who knows about this stuff and is sober to help you stay safe.
Cannabis and Shrooms: A Popular But Potent Pair
Using weed and psilocybin (from magic mushrooms) together is common for people who try psychedelics and those who just use them sometimes. It's popular, but it’s not always easy to guess what will happen. Some find it makes feelings deeper and visuals stronger. Others say it causes scary visions, worry, or even feeling sick.
Why People Mix Cannabis and Psilocybin
Surveys show almost half of psychedelic users have tried this mix (Janikian, 2024). Common reasons are:
- To help with feeling sick when shrooms start to work.
- To get into thinking about yourself.
- To make visuals stronger.
- To make the comedown easier or feel better at the end.
But even though weed usually makes you relaxed, happy, and changes how you see things, mixed with shrooms, these effects can be much stronger. Feeling loose from weed might help you let go into the strange parts of psilocybin, but it can also make it harder to deal with tough emotions.
Timing Matters
- During Come-Up (0–1.5 hours): Weed here might stop you from feeling sick or stiff. But, it can also make you more worried as the trip gets stronger.
- Peak Phase (2–4 hours): Adding weed now can make visuals and strange thoughts stronger. It could also go wrong and make you confused.
- After Peak (4–6 hours): Many think this is the safest time to use a little weed to think creatively or calm down.
User Experiences
Some users say the mix feels more spiritual or real. Others warn against smoking without thinking during a trip, because it can make things too strong.
“Weed makes me less worried, which helps me let go and enjoy the shroom trip,” one user said.
Another said, “It was too much too fast. I felt like I was drowning in visuals.”
Best Practices
- Use weed with low THC and high CBD for a smoother time.
- Think about how much weed you can handle. Even if you use weed a lot, a trip can make it feel stronger.
- Don't use edibles or concentrates unless you know how you will react.
Cannabis and LSD: A Trip Within a Trip
LSD (lysergic acid diethylamide) trips last a long time, often 8-12 hours. Mixing LSD with weed can cause sudden strong moments and deeper self-reflection. It can make a trip great or suddenly bad.
The Unique Rhythm of LSD
LSD trips build up and last a while. People often say they feel connected, see things differently, time feels strange, or they think more creatively. When weed is added, these things can change fast.
- The smooth feeling of LSD can suddenly become body stress, confusion, or visuals that break apart when weed is added.
- But weed might also make the psychedelic dream better, making music sound amazing or colors look unreal.
Mood-Dependent Outcomes
If you feel good and steady on your LSD trip, weed might make those feelings better. But if you are worried, unsure, or mixed up, weed could make you more lost in bad thoughts.
“I saw I was moving smoke with my thoughts... I couldn’t stop wondering if I was real,” one person using LSD and weed said.
Even people who use weed often say LSD changes how weed “feels” a lot.
Advice for Pairing LSD and Cannabis
- Wait at least 3–4 hours into your trip before using weed.
- Start with one puff or a little vape to see how it works.
- Don't use sativa strains. They can make you too energetic and stressed.
Cannabis and MDMA: Happy Boost or Quiet Problem?
MDMA (3,4-Methylenedioxymethamphetamine), also called ecstasy or molly, makes you feel very open and excited. It's not really a psychedelic, but people who try psychedelics talk about it because it makes you feel empathy.
How Cannabis Interacts with MDMA
The two can work well together, mostly when you feel very emotional. Weed might make MDMA's effects stronger:
- Body happiness (warm, light feeling).
- Emotional connection (mostly with music or people).
- Visual changes (lines following things or colors changing a bit).
But both can speed up your heart and raise blood pressure. This can be risky if you are dancing a lot, in a hot place, or not drinking enough water.
“It made my happy feelings better, like a floating, magic bubble. But later, my heart was racing, and I felt shaky,” one user shared.
Best Use Timing with MDMA
- During Comedown (4–6+ hours): Weed is often used to make the sad feelings after MDMA less bad and to think about the night.
- During Peak (1–3 hours): It might make things better, but it can be too much for some people.
MDMA Mixing Tips
- Use weed with low THC near the end, not at the start.
- Drink lots of water. Herbal teas like chamomile can also help clean your system.
- Don’t mix weed concentrates or very strong THC stuff. Start with a little puff.
When Do Most People Smoke Weed While Tripping?
When you use weed during a trip can change things a lot. The table below shows common times and why people might use weed at those times:
| Trip Phase | Substance | Why People Mix It | Potential Outcome |
|---|---|---|---|
| Come-Up | Shrooms, LSD | Calm nerves, reduce feeling sick | May calm or make worry worse |
| Peak | LSD, MDMA | Make visuals/feelings stronger | Can be too much |
| After Peak | Shrooms, LSD | Think more, stronger visuals | Might trip again |
| Comedown | MDMA, LSD | Easier end, less crash | Smooth end or spacey feeling |
| End of Trip | Shrooms, LSD | Creative thought, help sleep | Might start trip again |
Can Cannabis Extend a Psychedelic Trip?
Yes, mostly near the end of your trip, weed can bring back visuals or trip-like thoughts. Some say it's like a space between tripping and being normal. This can be nice, but it can also be confusing or unwanted if you wanted to be done tripping.
Good Time or Lingering Trap?
- Good: Creative boost, ending feeling, more understanding.
- Bad: Tired mind, too much input, can't sleep.
Tip: If you want to use weed at the end of your trip, get a comfy place ready, with paper and pen or a sketchbook, and maybe music without words to help you relax back to normal.
Research on Cannabis-Psychedelic Synergy
Even though most talk about weed and psychedelics comes from users, some science is starting to check out how they work together.
CaaMTech’s Groundbreaking Patent
In 2021, CaaMTech got a patent for mixes that put cannabinoids (like THC and CBD) with psilocin and psilocybin. They wanted to use how they both work on serotonin receptors to help with mental problems (Justia, 2021).
This means:
- Weed and mushrooms might work together on 5-HT2A receptors. These are important for mood and seeing things.
- Future treatments might use mixes of molecules for therapy with psychedelics.
Warning: The Risk of HPPD
One of the less talked about risks of mixing weed and psychedelics is getting Hallucinogen Persisting Perception Disorder (HPPD). This is when visuals keep changing even after a trip. These can be:
- Seeing lines or afterimages all the time.
- Visual snow or flashing lights.
- Walls that look like they are breathing or floors moving.
According to Erowid, HPPD happens to about 0.12% to 4.2% of psychedelic users. The risk is higher for people who tend to feel disconnected or worried (Erowid, as said in Janikian, 2024).
Expert Insight
Dr. James Giordano warns that people with a family or personal history of schizophrenia, bipolar disorder, or psychosis from trauma should be very careful or not mix at all. This is because their brains are more sensitive to too much activity in the parts of the brain that control what you see.
Harm Reduction Tips for Mixing Weed and Psychedelics
If you are going to try mixing:
- Use weed with low THC or balance it with CBD.
- Wait between taking each drug. Don't take them all at once.
- Drink water often and eat light snacks.
- Test each drug alone with reagent kits if you can.
- Think about how your mental health is before, during, and after.
- Be careful about where you are. Pick safe, known, calm places.
- Have someone you trust with you or a sitter if trying a new mix.
Final Thoughts: A Personal Decision, Not a Trend
Mixing weed and psychedelics is not for everyone. Some say it brings great feelings, healing, or new ideas for art. Others have worry, disconnection, or lasting visual problems. Your brain is important and needs care.
If you are new to psychedelics, try each one alone before mixing them. Respect yourself, how your mind works, and your life right now.
For those who want to try, Zombie Mushrooms has easy grow kits to grow psilocybin mushrooms safely at home. This is a careful way to start with psychedelics.
Mixing weed and psychedelics can teach you things, but only if you are careful, plan it, and have support.
